Online courses directory (423)

This course considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior.

One of the best ways to understand the present is to understand the past. Evolutionary Biology is the study of the changes in life forms over time - changes that have occurred over millions of years as well as those that have occurred over just a few decades. In this course, we will look at the various mechanisms of evolution, how these mechanisms work, and how change is measured. The concepts you learn in this course will serve as a foundation for studying fossil records and current classification schemes in biology. We will begin the course by reviewing the evolutionary concepts of selection and speciation. We will then learn to measure evolutionary change through comparisons with the Hardy-Weinberg Equilibrium, to understand the process of change through Game Theory, and to interpret and classify changes by creating phylogenies. The course will wrap up with a look at the history of life according to the fossil record and a discussion of the broad range of life forms as they are currently classified. At the…

This course is the second installment of Single-Variable Calculus.  In Part I (MA101) [1], we studied limits, derivatives, and basic integrals as a means to understand the behavior of functions.  In this course (Part II), we will extend our differentiation and integration abilities and apply the techniques we have learned. Additional integration techniques, in particular, are a major part of the course.  In Part I, we learned how to integrate by various formulas and by reversing the chain rule through the technique of substitution.  In Part II, we will learn some clever uses of substitution, how to reverse the product rule for differentiation through a technique called integration by parts, and how to rewrite trigonometric and rational integrands that look impossible into simpler forms.  Series, while a major topic in their own right, also serve to extend our integration reach: they culminate in an application that lets you integrate almost any function you’d like. Integration allows us to calculat…

Surveys the literature on the cognitive and neural organization of human memory and learning. Includes consideration of working memory and executive control, episodic and semantic memory, and implicit forms of memory. Emphasizes integration of cognitive theory with recent insights from functional neuroimaging (e.g., fMRI and PET).

Cancer has existed among humans since humans themselves began and has been a subject of urgent interest from very early in our history.  What we call “cancer” consists of a number of different diseases with one fundamental similarity: they are all initiated by the unchecked proliferation and growth of cells in which the pathways and systems that normally control cell division and mortality are absent.  Cancer-cell abnormalities are often due to mutations of the genes that control the cell cycle and cell growth.  To understand cancer cells, then, one must first understand the processes that regulate normal cell cycles. This course will cover the origins of cancer and the genetic and cellular basis for cancer.  It will examine the factors that have been implicated in triggering cancers; the intercellular interactions involved in cancer proliferation; current treatments for cancer and how these are designed; and future research and treatment directions for cancer therapy.

Advanced Inorganic Chemistry is designed to give you the knowledge to explain everyday phenomena of inorganic complexes. You will study the various aspects of their physical and chemical properties and learn how to determine the practical applications that these complexes can have in industrial, analytical, and medicinal chemistry. This course will begin with the discussion of symmetry and point group theory and its applications in the field of vibrational spectroscopy. We will then study molecular orbital (MO) theory specifically applied to metal organic complexes. MO theory will be critical in understanding the following: 1) the relative position of ligands in the spectrochemical series, 2) the electronic transitions and related selection rules, and 3) the application of spectroscopy of metals. The course will then move onto the study of the oxidation states of transition metals and their redox properties. A firm grasp of the chemical redox properties of transition metals is critical to understanding thei…

The geologic record demonstrates that our environment has changed over a variety of time scales from seconds to billions of years. This course explores the many ways in which geologic processes control and modify the Earth's environment and serves as an introduction to Environmental Earth Science Field Course (12.120), which addresses field applications of these principles in the American Southwest.

Marine Biology is the study of ocean life.  As you might expect, life in salt water is vastly different from life in a terrestrial or freshwater environment due to factors like salinity, water circulation, and atmospheric pressure.  How, for example, can organisms living in salt water avoid dehydration?  How do organisms living in the depths of the ocean handle the immense pressure?  How do the environmental factors in marine communities affect biodiversity?  How do some animals manage to alternate between the demands of terrestrial life and the demands of marine life?  In this course, you will learn the answers to these questions and more.  This course will touch on a number of different subfields of biological study (including biochemistry, physiology, zoology, botany, and ecology) within the context of the ocean environment. You will start by learning about the ocean itself and its physical properties, as these properties influence the abundance, distribution, diversity, physiology, and behavior o…

Inorganic chemistry is a division of chemistry that studies metals, their compounds, and their reactivity.  Metal atoms can be bound to other metal atoms in alloys or metal clusters, to nonmetal elements in crystalline rocks, or to small organic molecules, such as a cyclopentadienyl anion in ferrocene.  These metal atoms can also be part of large biological molecules, as in the case of iron in hemoglobin (oxygen-carrier protein in the blood). In this course, you should not think of metals as you encounter them in your daily life (i.e., when you pick up a steel knife, a can of soda, or a gold necklace).  Instead, you should think of a metal as the central atom or ion in a molecule surrounded by other ions or small molecules called ligands.  Depending on what these ligands are, the metal-containing compound can acquire very different physical and chemical properties.  For example, when magnesium (in its ionic state) is bound to carbonate ions, it forms solid crystalline rocks, as in the dolomite rocks (c…

Molecular biology studies the molecular mechanisms of life, particularly those responsible for genes and their expression.  In the center of molecular biology are the nucleic acids, DNA and RNA, and how they contribute to the synthesis of proteins. After a historical introduction (Unit 1), this course describes the basic types of DNA and RNA structure and the molecular interactions that shape them (Unit 2).  Unit 3 describes how DNA is packaged within the cellular nucleus as chromosomes; in eukaryotes the DNA coils around histones to form nucleosomes that comprise the chromatin of the chromosomes.  The next three units describe the core processes of molecular biology: replication of DNA (Unit 4), transcription of DNA into messenger RNA (Unit 5), and translation of messenger RNA into a protein (Unit 6).  These are followed by modifications of these basic processes: regulation of gene expression (Unit 7), DNA mutation and repair (Unit 8), and DNA recombination and transposition (Unit 9). The course conclu…

This lab course supplements BIO102: Introduction to Evolutionary Biology and Ecology [1].  Although we cannot virtually replicate a true lab experience, this “lab” will allow you to become familiar with scientific thinking and techniques, and will enable you to explore some key principles of evolutionary biology and ecology. The material in this lab supplement directly relates to the material covered in the lecture and reading portion of the course.  While the lecture and reading portion focuses on big-picture concepts, here we will focus more on visual understanding, application, and practical use of your knowledge.  In each unit, you will work through tutorials related to important scientific concepts and then will be asked to think creatively about how your knowledge can be put to practical or experimental use. [1] http:///courses/bio102/…

Botany is the study of plants.  Because species in the plant kingdom have characteristics that make them distinct from any other form of life, they are particularly interesting subjects for the study of evolution and physiology.  For example, whereas most organisms are dependent on other organisms for energy, plants can capture energy directly from photons of light and convert it into a usable form through the process of photosynthesis.  For this reason, plants are referred to as the “producers” in a habitat.  Unlike the cells of other organisms, plant cells have rigid cell walls constructed from the inside out (rather than the outside in) during mitosis and cytokinesis.  Plants also have a variety of unique reproductive and dispersal mechanisms that allow them to quickly adapt to, occupy, and invade far-flung areas, despite their general immobility. In this course, you will learn the basics of plant biology.  We will begin with plant anatomy, learning the names and functions of all of the parts o…

In this course, you will study microscopic anatomy. The study of the structure of a cell, tissue, organ, or related feature is known as anatomy. Gross anatomy (or macroscopic anatomy) involves examining anatomical structures that can be seen with the naked eye, whereas microscopic anatomy is the examination of minute anatomical structures that cannot be observed without the help of visual enhancement, such as a microscope. The terms microscopic anatomy and histology (the study of microscopic structure of animal and plant tissue) are used interchangeably. Many times it will be necessary to survey gross anatomy so that when you focus in on the microscopic anatomy you will have a geographical idea of the location within the body. This course makes use of microscope slides of anatomical structures to aid in the discussions of anatomy. Unit 1 begins with an overview of basic cell structure. The study of cells is known as cytology. Cells contain numerous structures that can only be seen with the aid of specialize…

This introductory course in biology starts at the microscopic level, with molecules and cells.  Before we get into the specifics of cell structure and behavior, however, let’s take a cursory glance at the field of biology more generally.  Though biology as we know it today is a relatively new field, we have been studying living things since the beginning of recorded history.  The invention of the microscope was the turning point in the history of biology; it paved the way for scientists to discover bacteria and other tiny organisms, and ultimately led to the modern cell theory of biology. You will notice that, unlike the core program courses you took in chemistry and physics, introductory biology does not have many mathematical “laws” and “rules” and does not require much math.  Instead, you will learn a great number of new terms and concepts that will help you describe life at the smallest level.  Over the course of this semester, you will recognize the ways in which the tiniest of molecules…

This course will introduce you to the major concepts of and debates surrounding industrial and organizational psychology. Industrial and organizational psychology is the application of psychological research and theory to human interaction (both with other humans and with human factors, or machines and computers) in the workplace. The phrase “industrial and organizational psychology” (sometimes referred to as “I/O”) may be somewhat misleading, as the field deals less with actual organizations and/or industries and more with the people in these areas. As mentioned above, “I/O” is an applied psychological science, which means that it takes research findings and theories that may have originally been used to explain a general phenomenon of human behavior and applies them to human behavior in a specific setting (here, the workplace). Consider, for example, the fact that many jobs require applicants to take a personality test. Psychologists originally developed this test to detect and diagnose abnorm…

Physical Organic Chemistry covers the principles of chemical bonding, mechanisms of organic chemical reactions and stereochemistry. The important types of organic reactions are also discussed, with an emphasis on basic principles. As a part of this course, U-M students collaboratively created and edited Wikipedia articles. Student contributions can be found within the Sessions tab. Course Level: Graduate This Work, Chemistry 540 - Physical Organic Chemistry, by Anne McNeil is licensed under a Creative Commons Attribution-ShareAlike license.

This course uses an open textbook University of Michigan Chemical Engineering Process Dynamics and Controls. The articles in the open textbook (wikibook) are all written by teams of 3-4 senior chemical engineering students, and are peer-reviewed by other members of the class. Using this approach, the faculty and Graduate Student Instructors (GSIs) teaching the course act as managing editors, selecting broad threads for the text and suggesting references. In contrast to other courses, the students take an active role in their education by selecting which material in their assigned section is most useful and decide on the presentation approach. Furthermore, students create example problems that they present in poster sessions during class to help the other students master the material. Course Level: Undergraduate This Work, CHE 466 - Process Dynamics and Controls, by Peter J. Woolf is licensed under a Creative Commons Attribution license.

Immunology is the study of our immune system, a highly sophisticated system that defends us against all disease-causing invaders by identifying and neutralizing such threats. Even though we might get sick every now and then, the immune system does an incredible job of warding off infection given how many infectious agents (thousands!) we come into contact with every day. This becomes most apparent when a healthy individual compares himself or herself to an individual with little or no immune response who cannot survive in a normal environment and must rely on specialized rooms much cleaner than even a surgery room. Before the discovery of immunity, we used to associate sickness and disease with various superstitions and beliefs. Only with the discovery of bacteria, viruses, and our own cells did scientists slowly piece together the modern theory of our immune system. Our overall system can be broken down into two sub-systems, each with its own unique cells, molecules, and functions. Our cells are in turn capa…

This course is a continuation of CHEM103 [1]: Organic Chemistry I.  As you progress through the units below, you will continue to learn the different chemical reactions characteristic of each family of organic compounds.  We will focus on the four most important classes of reactions: electrophilic substitution at aromatic rings, nucleophilic addition at carbonyl compounds, hydrolysis of carboxylic acids, and carbon-carbon bond formation using enolates.  The enolate portion of this course will cover the reactivity of functional groups. We will also look at synthetic strategies for making simple, small organic molecules, using the knowledge of organic chemistry accumulated thus far.  At the end of this course, you will possess the tools you need to plan the synthesis of fairly complicated molecules, like those used in pharmaceutics.  From the perspective of a synthetic organic chemist, the two most challenging aspects of synthesizing drug molecules are the incorporation of  "molecular rings" (rings of 5…

How does the brain function? How does it interact with the body in order to control and mediate behaviors and actions? Though psychologists have long studied these questions, the workings of the brain remain, in large part, a mystery. In this course, we will explore the field of psychology devoted to the pursuit of these questions: neuropsychology or the study of the structure and function of the brain as it relates to psychological processes. We will study significant findings in the field, noting that technological improvements have often enabled substantial advancements in field research. You may, for example, take MRIs or PET scans  devices used to diagnose medical problems  for granted, but these have only relatively recently enabled researchers to study the brain in greater detail. While a formal background in biology is not required for this course, you will find that neuropsychology relies heavily on the discipline. In fact, psychologists and biologists have often explored similar issues, though t…